Diazaphilonic acid, a new azaphilone with telomerase inhibitory activity.

Throughour screening programofbioactive secondary metabolites of microbial origin, we have isolated a new azaphilone-type metabolite, diazaphilonic acid (Fig. 1). In this paper, we report the taxonomy of the producing strain, production, isolation, physico-chemical properties and biological activities of diazaphilonic acid. The mycological characteristics of the producing fungal strain PF1195 (Fig. 2) were as follows. Yellow colonies grew rapidly at 25°C on Czapek-yeast extract agar and malt extract agar. Ascomatawere abundantly produced and conidiogenesis was sparse and inconspicuous. Ascomata were non-ostiolate, yellow, formed a telaperidium, and matured within 14 days. Ascomatal pp.412 414